Abstract
Objective: We aimed to assess the association between migraine headache and incident dementia. Background: Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia. Methods: History of migraine was ascertained via questionnaire. Adjudicated cases of dementia were identified using cognitive tests, neuropsychological exams, and clinician review of suspected cases. Incident dementia was identified using adjudicated cases, follow-up calls, and surveillance of hospital and death codes. We assessed hazards of incident dementia by migraine status. Sex differences were also examined and stratified results were presented. Results: Analysis included 12,495 White and African American participants ages 51-70 with a median follow-up time of 21 years. Prevalence of dementia was 18.5% (1821/9955) among those with no migraine history, 15.8% (196/1243) among those with severe non-migraine heading, and 16.7% (233/1397) among migraineurs. There was no association between migraine and incident dementia [hazard ratio: 1.04 (0.91, 1.20)]. There was also no statistically significant interaction between sex and migraine status on risk of dementia. Conclusion: Despite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 946-953 |
| Number of pages | 8 |
| Journal | Headache |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2020 |
Bibliographical note
Funding Information:We would like to thank Sheila Burgard at the Collaborative Studies Coordinating Center at the University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC for technical data assistance. Dr. George is supported by National Heart, Lung, and Blood Institute (NHLBI) Training Grant T32HL007779. Dr. Hamedani is supported by NIH NINDS T32 NS061779‐10. Dr. Gottesman is supported by NIH grant K24 AG052573. The Atherosclerosis Risk in Communities study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). Neurocognitive data are collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA, and NIDCD), and with previous brain MRI examinations funded by R01‐HL70825 from the NHLBI. The authors thank the staff and participants of the ARIC study for their important contributions.
Funding Information:
We would like to thank Sheila Burgard at the Collaborative Studies Coordinating Center at the University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC for technical data assistance. Dr. George is supported by National Heart, Lung, and Blood Institute (NHLBI) Training Grant T32HL007779. Dr. Hamedani is supported by NIH NINDS T32 NS061779-10. Dr. Gottesman is supported by NIH grant K24 AG052573. The Atherosclerosis Risk in Communities study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). Neurocognitive data are collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA, and NIDCD), and with previous brain MRI examinations funded by R01-HL70825 from the NHLBI. The authors thank the staff and participants of the ARIC study for their important contributions.
Publisher Copyright:
© 2020 American Headache Society
Keywords
- dementia
- epidemiology
- headache
- migraine