MICUs protect the heart by regulating mitochondrial calcium

Ulas Ozkurede; Shanmugasundaram Pakkiriswami; Julia C. Liu

doi:10.1016/j.tips.2024.09.010

MICUs protect the heart by regulating mitochondrial calcium

Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Julia C. Liu

Physiology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.

Original language	English (US)
Pages (from-to)	950-952
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	45
Issue number	11
DOIs	https://doi.org/10.1016/j.tips.2024.09.010
State	Published - Nov 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Keywords

EMRE
MCU
MICU1
MICU2
calcium
heart
mitochondria

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tips.2024.09.010

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title = "MICUs protect the heart by regulating mitochondrial calcium",

abstract = "Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.",

keywords = "EMRE, MCU, MICU1, MICU2, calcium, heart, mitochondria",

author = "Ulas Ozkurede and Shanmugasundaram Pakkiriswami and Liu, \{Julia C.\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = nov,

doi = "10.1016/j.tips.2024.09.010",

language = "English (US)",

volume = "45",

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journal = "Trends in Pharmacological Sciences",

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T1 - MICUs protect the heart by regulating mitochondrial calcium

AU - Ozkurede, Ulas

AU - Pakkiriswami, Shanmugasundaram

AU - Liu, Julia C.

PY - 2024/11

Y1 - 2024/11

N2 - Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.

AB - Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.

KW - EMRE

KW - MCU

KW - MICU1

KW - MICU2

KW - calcium

KW - heart

KW - mitochondria

UR - https://www.scopus.com/pages/publications/85206317727

UR - https://www.scopus.com/inward/citedby.url?scp=85206317727&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2024.09.010

DO - 10.1016/j.tips.2024.09.010

M3 - Short survey

C2 - 39406593

AN - SCOPUS:85206317727

SN - 0165-6147

VL - 45

SP - 950

EP - 952

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 11

ER -

MICUs protect the heart by regulating mitochondrial calcium

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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