Microwave enabled umpulong mechanism based rapid and efficient four- and six-component domino formations of 2-(2′-azaaryl)imidazoles and anti-1,2-diarylethylbenzamides

Bo Jiang, Xiang Wang, Feng Shi, Shu Jiang Tu, Teng Ai, Austin Ballew, Guigen Li

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

(Chemical Equation Presented) Concise and efficient six-component and four-component domino approaches to anti-1,2-diarylethylbenzamides and highly substituted 2-(2′-azaaryl)imidazoles have been developed under solvent-free and microwave-irradiation conditions. The reactions showed a broad scope of substrates in which a wide range of common commercial aromatic aldehydes and heteroaryl nitriles can be used. The syntheses were finished within short periods (15-34 min) with good to excellent chemical yields and stereoselectivity that avoided tedious workup isolations. New mechanisms involving an umpolung have been proposed for these two reaction processes.

Original languageEnglish (US)
Pages (from-to)9486-9489
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number24
DOIs
StatePublished - Dec 18 2009

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