Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

Ravikrishna Dada; Garima Singh; Abhishek Pareek; Saeen Kausar; Srinivasarao Yaragorla

doi:10.1016/j.tetlet.2016.07.010

Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

Ravikrishna Dada
, Garima Singh
, Abhishek Pareek
, Saeen Kausar
, Srinivasarao Yaragorla

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free & solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds.

Original language	English (US)
Pages (from-to)	3739-3742
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2016.07.010
State	Published - 2016
Externally published	Yes

Bibliographical note

Funding Information:
RD, GS, and AP thank Central University of Rajasthan for the fellowship and SY thank Council of Scientific and Industrial Research (CSIR)-India for the financial support under Extramural Research Grant-No. 02(0200)/14/EMR-II .

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Benzylation
Catalyst & solvent free
Dehydration
Ethers
Microwave reaction
SN

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10.1016/j.tetlet.2016.07.010

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title = "Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst \& solvent free conditions",

abstract = "An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free \& solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds.",

keywords = "Benzylation, Catalyst \& solvent free, Dehydration, Ethers, Microwave reaction, SN",

author = "Ravikrishna Dada and Garima Singh and Abhishek Pareek and Saeen Kausar and Srinivasarao Yaragorla",

note = "Funding Information: RD, GS, and AP thank Central University of Rajasthan for the fellowship and SY thank Council of Scientific and Industrial Research (CSIR)-India for the financial support under Extramural Research Grant-No. 02(0200)/14/EMR-II . Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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language = "English (US)",

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T1 - Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

AU - Dada, Ravikrishna

AU - Singh, Garima

AU - Pareek, Abhishek

AU - Kausar, Saeen

AU - Yaragorla, Srinivasarao

N1 - Funding Information: RD, GS, and AP thank Central University of Rajasthan for the fellowship and SY thank Council of Scientific and Industrial Research (CSIR)-India for the financial support under Extramural Research Grant-No. 02(0200)/14/EMR-II . Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016

Y1 - 2016

N2 - An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free & solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds.

AB - An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free & solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds.

KW - Benzylation

KW - Catalyst & solvent free

KW - Dehydration

KW - Ethers

KW - Microwave reaction

KW - SN

UR - https://www.scopus.com/pages/publications/84978857962

UR - https://www.scopus.com/pages/publications/84978857962#tab=citedBy

U2 - 10.1016/j.tetlet.2016.07.010

DO - 10.1016/j.tetlet.2016.07.010

M3 - Article

AN - SCOPUS:84978857962

SN - 0040-4039

VL - 57

SP - 3739

EP - 3742

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

Abstract

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Keywords

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