Microtubule catastrophe and rescue.

Melissa K. Gardner, Marija Zanic, Jonathon Howard

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends of individual microtubules. The dynamic behavior at the end of an individual microtubule is termed 'dynamic instability'. This behavior manifests itself by periods of persistent microtubule growth interrupted by occasional switching to rapid shrinkage (called microtubule 'catastrophe'), and then by switching back from shrinkage to growth (called microtubule 'rescue'). In this review, we summarize recent findings which provide new insights into the mechanisms of microtubule catastrophe and rescue, and discuss the impact of these findings in regards to the role of microtubule dynamics inside of cells.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume25
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Microtubules
Axoneme
Spindle Apparatus
Cell Shape
Cellular Structures
Tubulin
Growth
Polymers

Cite this

Microtubule catastrophe and rescue. / Gardner, Melissa K.; Zanic, Marija; Howard, Jonathon.

In: Current Opinion in Cell Biology, Vol. 25, No. 1, 02.2013, p. 14-22.

Research output: Contribution to journalArticle

Gardner, Melissa K. ; Zanic, Marija ; Howard, Jonathon. / Microtubule catastrophe and rescue. In: Current Opinion in Cell Biology. 2013 ; Vol. 25, No. 1. pp. 14-22.
@article{448fc2a1b1664eb182afca68f9663c7b,
title = "Microtubule catastrophe and rescue.",
abstract = "Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends of individual microtubules. The dynamic behavior at the end of an individual microtubule is termed 'dynamic instability'. This behavior manifests itself by periods of persistent microtubule growth interrupted by occasional switching to rapid shrinkage (called microtubule 'catastrophe'), and then by switching back from shrinkage to growth (called microtubule 'rescue'). In this review, we summarize recent findings which provide new insights into the mechanisms of microtubule catastrophe and rescue, and discuss the impact of these findings in regards to the role of microtubule dynamics inside of cells.",
author = "Gardner, {Melissa K.} and Marija Zanic and Jonathon Howard",
year = "2013",
month = "2",
doi = "10.1016/j.ceb.2012.09.006",
language = "English (US)",
volume = "25",
pages = "14--22",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Microtubule catastrophe and rescue.

AU - Gardner, Melissa K.

AU - Zanic, Marija

AU - Howard, Jonathon

PY - 2013/2

Y1 - 2013/2

N2 - Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends of individual microtubules. The dynamic behavior at the end of an individual microtubule is termed 'dynamic instability'. This behavior manifests itself by periods of persistent microtubule growth interrupted by occasional switching to rapid shrinkage (called microtubule 'catastrophe'), and then by switching back from shrinkage to growth (called microtubule 'rescue'). In this review, we summarize recent findings which provide new insights into the mechanisms of microtubule catastrophe and rescue, and discuss the impact of these findings in regards to the role of microtubule dynamics inside of cells.

AB - Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends of individual microtubules. The dynamic behavior at the end of an individual microtubule is termed 'dynamic instability'. This behavior manifests itself by periods of persistent microtubule growth interrupted by occasional switching to rapid shrinkage (called microtubule 'catastrophe'), and then by switching back from shrinkage to growth (called microtubule 'rescue'). In this review, we summarize recent findings which provide new insights into the mechanisms of microtubule catastrophe and rescue, and discuss the impact of these findings in regards to the role of microtubule dynamics inside of cells.

UR - http://www.scopus.com/inward/record.url?scp=84875849074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875849074&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2012.09.006

DO - 10.1016/j.ceb.2012.09.006

M3 - Article

VL - 25

SP - 14

EP - 22

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 1

ER -