Microscopic and macroscopic evaluation of emboli captured during angioplasty and stent procedures in extracranial vertebral and internal carotid arteries

Afshin A. Divani, Tamara L. Berezina, Jingying Zhou, Reza Pakdaman, M. Fareed K. Suri, Adnan I. Qureshi

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purpose: To compare the quantities of emboli dislodged during percutaneous transluminal angioplasty/stenting in the vertebral artery (VA) with those released during stent placement in the internal carotid artery (ICA). Methods: Macroscopic images of distal protection devices (DPD) used during 30 stent procedures in 16 ICAs (11 men; mean age 64.6±10.6 years) and 14 VAs (9 men; mean age 67.1 ±9.8 years) were reviewed. The amount of captured embolic debris was calculated and expressed as a proportion to the size of the filter. Histological examinations were performed to characterize the material trapped in the filters. Results: Relative to the size of the filter, the proportion of captured debris ranged from 0.1% to ∼22% in the ostial VA filters and from 0.1% to ∼21% in the filters used in the ICA procedures (p=NS). Plaque fragments with or without thrombus were discovered in the histological examinations of captured material. There were no significant differences in the characteristics of the debris between the 2 vascular regions, nor did sex, race, or plaque morphology correlate significantly with the proportion of captured debris. However, the severity of stenosis was significantly (p<0.029) greater in the ICA (73%±0.11%) than the VA (63%±0.09%) territory. Conclusion: The study suggests that the frequency and amount of captured emboli during stent procedures in ICA and ostial VAs are comparable. Therefore, the use of a DPD for stent placement in the vertebral artery may be advisable.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Endovascular Therapy
Volume15
Issue number3
DOIs
StatePublished - Jun 1 2008

Keywords

  • Angioplasty
  • Cerebral protection devices
  • Distal protection
  • Embolism
  • Internal carotid artery
  • Neuroprotection
  • Stenosis
  • Stent
  • Thrombus
  • Vertebral artery

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