Micrornas in the malignant transformation process

Anne E Sarver, LIHUA LI, Reena Kartha, Subree Subramanian

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Many cancers originate as benign neoplasms that transform into malignant cancerous tumors in a multistep progression that is regulated, in part, by microRNAs. Benign neoplasms, by defi nition, lack the ability to invade adjacent tissues or spread to distant sites through metastasis. The benign to malignant transition is a critical intervention stage as tumors diagnosed in subsequent nonlocalized and malignant stages are exponentially more diffi cult to treat successfully. This chapter explores the critical roles that microRNAs play in the transformation from benign to malignant in four representative cancers: colorectal cancer, pancreatic cancer, malignant peripheral nerve sheath tumor, and prostate cancer. Understanding how these microRNAs control this progression and transformation will lead to new therapeutic targets and diagnostic biomarkers, resulting in improved treatments and patient outcomes.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-21
Number of pages21
DOIs
StatePublished - Jan 1 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume889
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

MicroRNAs
Tumors
Neoplasms
Biomarkers
Tissue
Neurilemmoma
Pancreatic Neoplasms
Colorectal Neoplasms
Prostatic Neoplasms
Neoplasm Metastasis

Keywords

  • Benign to malignant transformation
  • Biomarkers
  • Colorectal cancer
  • Malignant peripheral nerve sheath tumor
  • MicroRNA
  • Pancreatic cancer
  • Prostate cancer

Cite this

Sarver, A. E., LI, LIHUA., Kartha, R., & Subramanian, S. (2015). Micrornas in the malignant transformation process. In Advances in Experimental Medicine and Biology (pp. 1-21). (Advances in Experimental Medicine and Biology; Vol. 889). Springer New York LLC. https://doi.org/10.1007/978-3-319-23730-5_1

Micrornas in the malignant transformation process. / Sarver, Anne E; LI, LIHUA; Kartha, Reena; Subramanian, Subree.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2015. p. 1-21 (Advances in Experimental Medicine and Biology; Vol. 889).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sarver, AE, LI, LIHUA, Kartha, R & Subramanian, S 2015, Micrornas in the malignant transformation process. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 889, Springer New York LLC, pp. 1-21. https://doi.org/10.1007/978-3-319-23730-5_1
Sarver AE, LI LIHUA, Kartha R, Subramanian S. Micrornas in the malignant transformation process. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2015. p. 1-21. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-23730-5_1
Sarver, Anne E ; LI, LIHUA ; Kartha, Reena ; Subramanian, Subree. / Micrornas in the malignant transformation process. Advances in Experimental Medicine and Biology. Springer New York LLC, 2015. pp. 1-21 (Advances in Experimental Medicine and Biology).
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