MicroRNAs in opioid pharmacology

Cheol Kyu T Hwang, Yadav Wagley, Ping-Yee Law, Li-Na Wei, Horace H Loh

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


MicroRNAs (miRNA), a class of ~22-nucleotide RNA molecules, are important gene regulators that bind to the target sites of mRNAs to inhibit the gene expressions either through translational inhibition or mRNA destabilization. There are growing evidences that miRNAs have played several regulatory roles in opioid pharmacology. Like other research fields such as cancer biology, the area where numerous miRNAs are found to be involved in gene regulation, we assume that in opioid studies including research fields of drug additions and opioid receptor regulation, there may be more miRNAs waiting to be discovered. This review will summarize our current knowledge of miRNA functions on opioids biology and briefly describe future research directions of miRNAs related to opioids.

Original languageEnglish (US)
Pages (from-to)808-819
Number of pages12
JournalJournal of Neuroimmune Pharmacology
Issue number4
StatePublished - Dec 2012


  • Addiction
  • Fentanyl
  • GPCR
  • Morphine
  • Opioid receptor
  • miRNA


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