MicroRNA as Biomarkers of Malignant Mesothelioma

C. D. Hoang; Robert A Kratzke

doi:10.1016/B978-0-12-800553-8.00008-1

MicroRNA as Biomarkers of Malignant Mesothelioma

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Malignant pleural mesothelioma is a disease with poor prognosis and no cure. Worldwide, the incidence of this cancer problem continues to rise. The biology and tumorigenesis of this complex mesenchymal-type tumor remains incompletely understood. Over the past decade, emerging evidence has demonstrated that microRNAs, small nonprotein coding single-strand RNA negatively regulating gene expression, are deranged and exert significant biologic effects in multiple malignancies. This review will provide an update of the current state of microRNA translational research aimed at unraveling the novel biomarkers pertinent in several clinical problems of mesothelioma.

Original language	English (US)
Title of host publication	Translating MicroRNAs to the Clinic
Publisher	Elsevier Inc.
Pages	203-221
Number of pages	19
ISBN (Print)	9780128005538
DOIs	https://doi.org/10.1016/B978-0-12-800553-8.00008-1
State	Published - Jan 1 2017

Keywords

Asbestos
Biomarker
Biphasic
Epithelioid
Gene
Interactome
Mesothelioma
MicroRNA
Microarray
Sarcomatoid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-800553-8.00008-1

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abstract = "Malignant pleural mesothelioma is a disease with poor prognosis and no cure. Worldwide, the incidence of this cancer problem continues to rise. The biology and tumorigenesis of this complex mesenchymal-type tumor remains incompletely understood. Over the past decade, emerging evidence has demonstrated that microRNAs, small nonprotein coding single-strand RNA negatively regulating gene expression, are deranged and exert significant biologic effects in multiple malignancies. This review will provide an update of the current state of microRNA translational research aimed at unraveling the novel biomarkers pertinent in several clinical problems of mesothelioma.",

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doi = "10.1016/B978-0-12-800553-8.00008-1",

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AU - Kratzke, Robert A

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N2 - Malignant pleural mesothelioma is a disease with poor prognosis and no cure. Worldwide, the incidence of this cancer problem continues to rise. The biology and tumorigenesis of this complex mesenchymal-type tumor remains incompletely understood. Over the past decade, emerging evidence has demonstrated that microRNAs, small nonprotein coding single-strand RNA negatively regulating gene expression, are deranged and exert significant biologic effects in multiple malignancies. This review will provide an update of the current state of microRNA translational research aimed at unraveling the novel biomarkers pertinent in several clinical problems of mesothelioma.

AB - Malignant pleural mesothelioma is a disease with poor prognosis and no cure. Worldwide, the incidence of this cancer problem continues to rise. The biology and tumorigenesis of this complex mesenchymal-type tumor remains incompletely understood. Over the past decade, emerging evidence has demonstrated that microRNAs, small nonprotein coding single-strand RNA negatively regulating gene expression, are deranged and exert significant biologic effects in multiple malignancies. This review will provide an update of the current state of microRNA translational research aimed at unraveling the novel biomarkers pertinent in several clinical problems of mesothelioma.

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KW - MicroRNA

KW - Microarray

KW - Sarcomatoid

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M3 - Chapter

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BT - Translating MicroRNAs to the Clinic

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ER -

MicroRNA as Biomarkers of Malignant Mesothelioma

Abstract

Keywords

UN SDGs

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