Abstract
The study of regulatory non-coding RNAs has deepened our understanding of cancer on the molecular and clinical front. MicroRNAs, which encompass over 1000 short, endogenous nucleic acids, include important candidates that drive carcinogenesis. In this discussion, we review the literature on miR-135b, purporting its role as an oncogene in multiple cancers, and we highlight STAT3 inhibition as a potential therapeutic strategy mediated by miR-135b and demonstrate particular clinical relevance to colon cancer.
Original language | English (US) |
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Article number | Article 268 |
Journal | Frontiers in Oncology |
Volume | 3 OCT |
DOIs | |
State | Published - 2013 |
Keywords
- Colon cancer
- EGFR
- MiR-135b
- MicroRNAs
- STAT3