MicroRNA-135b and its circuitry networks as potential therapeutic targets in colon cancer

Rohini Khatri, Subree Subramanian

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The study of regulatory non-coding RNAs has deepened our understanding of cancer on the molecular and clinical front. MicroRNAs, which encompass over 1000 short, endogenous nucleic acids, include important candidates that drive carcinogenesis. In this discussion, we review the literature on miR-135b, purporting its role as an oncogene in multiple cancers, and we highlight STAT3 inhibition as a potential therapeutic strategy mediated by miR-135b and demonstrate particular clinical relevance to colon cancer.

Original languageEnglish (US)
Article numberArticle 268
JournalFrontiers in Oncology
Volume3 OCT
DOIs
StatePublished - Dec 31 2013

Fingerprint

MicroRNAs
Colonic Neoplasms
Untranslated RNA
Oncogenes
Nucleic Acids
Neoplasms
Carcinogenesis
Therapeutics

Keywords

  • Colon cancer
  • EGFR
  • MiR-135b
  • MicroRNAs
  • STAT3

Cite this

MicroRNA-135b and its circuitry networks as potential therapeutic targets in colon cancer. / Khatri, Rohini; Subramanian, Subree.

In: Frontiers in Oncology, Vol. 3 OCT, Article 268, 31.12.2013.

Research output: Contribution to journalArticle

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