MicroRNA-135b and its circuitry networks as potential therapeutic targets in colon cancer

Rohini Khatri, Subbaya Subramanian

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The study of regulatory non-coding RNAs has deepened our understanding of cancer on the molecular and clinical front. MicroRNAs, which encompass over 1000 short, endogenous nucleic acids, include important candidates that drive carcinogenesis. In this discussion, we review the literature on miR-135b, purporting its role as an oncogene in multiple cancers, and we highlight STAT3 inhibition as a potential therapeutic strategy mediated by miR-135b and demonstrate particular clinical relevance to colon cancer.

Original languageEnglish (US)
Article numberArticle 268
JournalFrontiers in Oncology
Volume3 OCT
DOIs
StatePublished - 2013

Keywords

  • Colon cancer
  • EGFR
  • MiR-135b
  • MicroRNAs
  • STAT3

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