Abstract
Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.
Original language | English (US) |
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Pages (from-to) | 16-29 |
Number of pages | 14 |
Journal | British Journal of Haematology |
Volume | 174 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2016 |
Bibliographical note
Publisher Copyright:© 2016 John Wiley & Sons Ltd
Keywords
- Biomarker
- Extracellular vesicle
- Flow cytometry
- Microparticle
- Sickle cell anaemia
PubMed: MeSH publication types
- Journal Article
- Review