Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.
Bibliographical noteFunding Information:
The authors acknowledge funding from the National Heart and Lung Institute UO1HL117659, 1UL1TR001111 and the Doris Duke Charitable Foundation grant # 2013123 (NSK).
© 2016 John Wiley & Sons Ltd
- Extracellular vesicle
- Flow cytometry
- Sickle cell anaemia
PubMed: MeSH publication types
- Journal Article