Microparticles in sickle cell anaemia: Promise and pitfalls

Robert P. Hebbel, Nigel S. Key

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.

Original languageEnglish (US)
Pages (from-to)16-29
Number of pages14
JournalBritish Journal of Haematology
Volume174
Issue number1
DOIs
StatePublished - Jul 1 2016

Bibliographical note

Funding Information:
The authors acknowledge funding from the National Heart and Lung Institute UO1HL117659, 1UL1TR001111 and the Doris Duke Charitable Foundation grant # 2013123 (NSK).

Publisher Copyright:
© 2016 John Wiley & Sons Ltd

Keywords

  • Biomarker
  • Extracellular vesicle
  • Flow cytometry
  • Microparticle
  • Sickle cell anaemia

PubMed: MeSH publication types

  • Journal Article
  • Review

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