Micronutrient needs of the developing brain: Priorities and assessment

Anita J. Fuglestad, Sara E Ramel, Michael K Georgieff

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Poor nutrition can have a significant impact on the physical, emotional, behavioral, and cognitive development of infants and young children. Although food insecurity does not occur to the same degree in the United States as in developing nations, the diets of many pregnant women and young children lack sufficient amounts of specific nutrients to support optimal functioning.1 Although all nutrients are required to support neurodevelopment, research studies in animal models and human populations show that certain nutrients are particularly important during the first years of life to support rapidly developing brain systems. The neurodevelopmental effects of a given nutrient are based on that nutrient’s metabolic role in regional brain development, the timing of the deficiency, and the degree and duration of the deficiency.2,3 Depending on the metabolic pathways and the structural components in which a nutrient is involved in the central nervous system (CNS), neuroanatomy, neurophysiology, and/or neurochemistry may be disrupted, each of which will result in altered neuronal function. Neuroanatomical changes include effects on cell proliferation, as well as cell differentiation, including synaptogenesis and dendritic arborization.4,5 Neurophysiological changes often affect signal propagation or changes in metabolism, while neurochemical changes involve neurotransmitter and receptor synthesis.6,7 These CNS changes may be region specific rather than global, as there is often regional sensitivity to a given deficiency.

Original languageEnglish (US)
Title of host publicationMicronutrients and Brain Health
PublisherCRC Press
Pages93-115
Number of pages23
ISBN (Electronic)9781420073522
ISBN (Print)9781420073515
StatePublished - Jan 1 2009

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Micronutrients
Food
Brain
Central Nervous System
Neurochemistry
Neuroanatomy
Neurophysiology
Neurotransmitter Receptor
Food Supply
Child Development
Metabolic Networks and Pathways
Developing Countries
Pregnant Women
Cell Differentiation
Animal Models
Cell Proliferation
Diet
Research
Population

Cite this

Fuglestad, A. J., Ramel, S. E., & Georgieff, M. K. (2009). Micronutrient needs of the developing brain: Priorities and assessment. In Micronutrients and Brain Health (pp. 93-115). CRC Press.

Micronutrient needs of the developing brain : Priorities and assessment. / Fuglestad, Anita J.; Ramel, Sara E; Georgieff, Michael K.

Micronutrients and Brain Health. CRC Press, 2009. p. 93-115.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fuglestad, AJ, Ramel, SE & Georgieff, MK 2009, Micronutrient needs of the developing brain: Priorities and assessment. in Micronutrients and Brain Health. CRC Press, pp. 93-115.
Fuglestad AJ, Ramel SE, Georgieff MK. Micronutrient needs of the developing brain: Priorities and assessment. In Micronutrients and Brain Health. CRC Press. 2009. p. 93-115
Fuglestad, Anita J. ; Ramel, Sara E ; Georgieff, Michael K. / Micronutrient needs of the developing brain : Priorities and assessment. Micronutrients and Brain Health. CRC Press, 2009. pp. 93-115
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