Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulation

K. Takahashi, M. Matsuo, T. Banno, T. Toyota

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site. In the presence of divalent metal ions and heat stimulation, we observed transition of the self-assembly, which results in the formation of a three-dimensional network structure. To our knowledge, this is also the first report of heat-induced micrometer-sized molecular self-assembly of molecules that carry biological information.

Original languageEnglish (US)
Pages (from-to)7053-7058
Number of pages6
JournalSoft Matter
Issue number35
StatePublished - Jul 25 2015

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Publisher Copyright:
© The Royal Society of Chemistry 2015.


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