Microglial Self-Recognition STINGs in A-T Neurodegeneration

Austin Ferro, Carrie Sheeler, Marija Cvetanovic

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

Original languageEnglish (US)
Pages (from-to)753-755
Number of pages3
JournalTrends in Neurosciences
Volume42
Issue number11
DOIs
StatePublished - Nov 2019

Keywords

  • ATM
  • NF-κB
  • ataxia telangiectasia
  • microglia

PubMed: MeSH publication types

  • Journal Article
  • Comment

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