Abstract
Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.
Original language | English (US) |
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Pages (from-to) | 753-755 |
Number of pages | 3 |
Journal | Trends in Neurosciences |
Volume | 42 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2019 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Ltd
Keywords
- ATM
- NF-κB
- ataxia telangiectasia
- microglia