Microfluidic model of sickle cell pathophysiology

D. K. Wood, J. M. Higgins, L. Mahadevan, S. N. Bhatia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a minimal microfluidic device that allows the study of whole blood rheology in vitro as a function of key biological and physical parameters. We apply this platform to the study of sickle cell disease, a condition for which there are no analytical tools capable of assessing disease severity or predicting treatment efficacy. We demonstrate that our system can distinguish blood samples from patients with severe and benign disease based on rheology. This device could be a powerful tool for optimizing existing treatments of sickle cell disease as well as a platform for developing new therapies.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1379-1381
Number of pages3
StatePublished - Dec 1 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Blood rheology
  • Drug development
  • Hemoglobinopathy
  • Microfluidic analytical techniques
  • Sickle cell disease

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