Microfluidic devices for the analysis of single cells: leaving no protein uncounted.

Marian Navratil, Christofer E. Whiting, Edgar Arriaga

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Microfluidic devices are revolutionizing bioanalysis, and designs capable of detecting single protein molecules are now available. Two recently described microfluidic devices provide information on the number of beta(2)-adrenergic receptors in individual cultured insect cells and measure the degradation of phycobilisomes in individual cyanobacteria, respectively. This latter experiment, which included the analysis of three single cells in parallel, heralds a bright future for high-throughput single-cell analyzers. These devices could greatly advance research in signal transduction and studies of the effects of environmental stimuli or xenobiotics on cellular responses.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2007
Issue number388
DOIs
StatePublished - Jun 16 2007

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