TY - JOUR
T1 - Microbiota transplant therapy and autism
T2 - lessons for the clinic
AU - Adams, James B.
AU - Borody, Thomas J.
AU - Kang, Dae Wook
AU - Khoruts, Alexander
AU - Krajmalnik-Brown, Rosa
AU - Sadowsky, Michael J.
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/11/2
Y1 - 2019/11/2
N2 - Introduction: The purpose of this review is to discuss Microbiota Transplant Therapy (MTT), a type of intensive intestinal microbiota transplantation (IMT), for people with autism spectrum disorders (ASD) and chronic gastrointestinal disorders (constipation and/or diarrhea). Areas covered: This paper briefly reviews IMT, gastrointestinal symptoms and gastrointestinal bacteria in children with ASD, and results and lessons learned from intensive MTT for autism. Expert opinion: An open-label study and a two-year follow-up suggest that MTT is relatively safe and effective in significantly reducing gastrointestinal disorders and autism symptoms, changing the gut microbiome structure, and increasing gut microbial diversity. Further research with larger, randomized, double-blind, placebo-controlled studies is warranted.
AB - Introduction: The purpose of this review is to discuss Microbiota Transplant Therapy (MTT), a type of intensive intestinal microbiota transplantation (IMT), for people with autism spectrum disorders (ASD) and chronic gastrointestinal disorders (constipation and/or diarrhea). Areas covered: This paper briefly reviews IMT, gastrointestinal symptoms and gastrointestinal bacteria in children with ASD, and results and lessons learned from intensive MTT for autism. Expert opinion: An open-label study and a two-year follow-up suggest that MTT is relatively safe and effective in significantly reducing gastrointestinal disorders and autism symptoms, changing the gut microbiome structure, and increasing gut microbial diversity. Further research with larger, randomized, double-blind, placebo-controlled studies is warranted.
KW - Autism
KW - constipation
KW - diarrhea
KW - fecal microbiota transplant
KW - gastrointestinal symptoms
KW - intestinal microbiota transplant
KW - microbiota transplant therapy
KW - vancomycin
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U2 - 10.1080/17474124.2019.1687293
DO - 10.1080/17474124.2019.1687293
M3 - Article
C2 - 31665947
AN - SCOPUS:85075009333
SN - 1747-4124
VL - 13
SP - 1033
EP - 1037
JO - Expert Review of Gastroenterology and Hepatology
JF - Expert Review of Gastroenterology and Hepatology
IS - 11
ER -