Microbiome in the hair follicle of androgenetic alopecia patients

Bryan Siu Yin Ho, Eliza Xin Pei Ho, Collins Wenhan Chu, Srinivas Ramasamy, Mei Bigliardi-Qi, Paola Florez de Sessions, Paul L Bigliardi

Research output: Contribution to journalArticle

Abstract

Androgenetic alopecia is the most common form of hair loss in males. It is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understood. We therefore analyzed the microbiome of hair follicles from hair loss patients and the healthy. Hair follicles were extracted from occipital and vertex region of hair loss patients and healthy volunteers and further dissected into middle and lower compartments. The microbiome was then characterized by 16S rRNA sequencing. Distinct microbial population were found in the middle and lower compartment of hair follicles. Middle hair compartment was predominated by Burkholderia spp. and less diverse; while higher bacterial diversity was observed in the lower hair portion. Occipital and vertex hair follicles did not show significant differences. In hair loss patients, miniaturized vertex hair houses elevated Propionibacterium acnes in the middle and lower compartments while non-miniaturized hair of other regions were comparable to the healthy. Increased abundance of P. acnes in miniaturized hair follicles could be associated to elevated immune response gene expression in the hair follicle.

Original languageEnglish (US)
Pages (from-to)e0216330
JournalPloS one
Volume14
Issue number5
DOIs
StatePublished - Jan 1 2019

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hair follicles
Hair Follicle
alopecia
Microbiota
Alopecia
Hair
hairs
Propionibacterium acnes
Burkholderia
Occipital Lobe
Gene expression
Genetic Predisposition to Disease
volunteers
microbiome
Healthy Volunteers
immune response
ribosomal RNA
microorganisms
Gene Expression
gene expression

PubMed: MeSH publication types

  • Journal Article

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Microbiome in the hair follicle of androgenetic alopecia patients. / Ho, Bryan Siu Yin; Ho, Eliza Xin Pei; Chu, Collins Wenhan; Ramasamy, Srinivas; Bigliardi-Qi, Mei; de Sessions, Paola Florez; Bigliardi, Paul L.

In: PloS one, Vol. 14, No. 5, 01.01.2019, p. e0216330.

Research output: Contribution to journalArticle

Ho BSY, Ho EXP, Chu CW, Ramasamy S, Bigliardi-Qi M, de Sessions PF et al. Microbiome in the hair follicle of androgenetic alopecia patients. PloS one. 2019 Jan 1;14(5):e0216330. https://doi.org/10.1371/journal.pone.0216330
Ho, Bryan Siu Yin ; Ho, Eliza Xin Pei ; Chu, Collins Wenhan ; Ramasamy, Srinivas ; Bigliardi-Qi, Mei ; de Sessions, Paola Florez ; Bigliardi, Paul L. / Microbiome in the hair follicle of androgenetic alopecia patients. In: PloS one. 2019 ; Vol. 14, No. 5. pp. e0216330.
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