Abstract
1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'hydroxyflavone, 3'4'dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'hydroxyisoflavone and 3'4'dihydroxyisoflavone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 363-373 |
| Number of pages | 11 |
| Journal | Xenobiotica |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1990 |