Microbiological transformation of flavone and isoflavone

Abdel Rahim S. Ibrahim, Yusuf J Abul-Hajj

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'hydroxyflavone, 3'4'dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'hydroxyisoflavone and 3'4'dihydroxyisoflavone.

Original languageEnglish (US)
Pages (from-to)363-373
Number of pages11
JournalXenobiotica
Volume20
Issue number4
DOIs
StatePublished - Jan 1 1990

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