Microbiological transformation of chromone, chromanone, and ring a hydroxyflavones

Yusuf J Abul-Hajj

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38 Scopus citations


Microbial transformation of chromone, chromanone, and 3 ring A hydroxyflavones (5-hydroxy-, 6-hydroxy-, and 7-hydroxyflavones) was attempted using thirty-two microorganisms. While chromone was not biotransformed, chromanone was transformed to chromone and chromanol by Aspergillus niger in 2% yield. Ring A hydroxylated flavones were transformed to the corresponding C-4ʹ hydroxylated metabolites, and the yields and rate of product formation were found to correlate with the distance between the C-4 carbonyl group and the hydroxyl group in ring A.

Original languageEnglish (US)
Pages (from-to)1471-1478
Number of pages8
JournalJournal of Natural Products
Issue number6
StatePublished - Jan 1 1990


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