Microbiological assessment of polymyxin B components tested alone and in combination

Zahra Kassamali; Randall A. Prince; Larry H. Danziger; John C. Rotschafer; Paul R. Rhomberg; Ronald N. Jones

doi:10.1128/AAC.01021-15

Microbiological assessment of polymyxin B components tested alone and in combination

Zahra Kassamali, Randall A. Prince, Larry H. Danziger, John C. Rotschafer, Paul R. Rhomberg, Ronald N. Jones

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.

Original language	English (US)
Pages (from-to)	7823-7825
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01021-15
State	Published - Dec 1 2015

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© 2015, American Society for Microbiology. All Rights Reserved.

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abstract = "We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.",

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AU - Danziger, Larry H.

AU - Rotschafer, John C.

AU - Rhomberg, Paul R.

AU - Jones, Ronald N.

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Microbiological assessment of polymyxin B components tested alone and in combination

Abstract

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