Abstract
We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7823-7825 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 59 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2015 |
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Kassamali, Z., Prince, R. A., Danziger, L. H., Rotschafer, J. C., Rhomberg, P. R., & Jones, R. N. (2015). Microbiological assessment of polymyxin B components tested alone and in combination. Antimicrobial agents and chemotherapy, 59(12), 7823-7825. https://doi.org/10.1128/AAC.01021-15