Microbiological assessment of polymyxin B components tested alone and in combination

Zahra Kassamali, Randall A. Prince, Larry H. Danziger, John C. Rotschafer, Paul R. Rhomberg, Ronald N. Jones

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.

Original languageEnglish (US)
Pages (from-to)7823-7825
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2015

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