Microbial production and biomedical applications of lovastatin

A. Seenivasan, S. Subhagar, R. Aravindan, T. Viruthagiri

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. Lovastatin acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by fermentation decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review deals with the structure, biosynthesis, various modes of fermentation and applications of lovastatin.

Original languageEnglish (US)
Pages (from-to)701-709
Number of pages9
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number6
DOIs
StatePublished - Feb 1 2008

Keywords

  • Biomedical applications
  • Fermentation
  • HMG-CoA reductase
  • High density lipoprotein (HDL)
  • Lovastatin
  • Low density lipoprotein (LDL)

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