MHC class la-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory respose

Sara E. Hamilton, Brandon B. Porter, Kelly A. Nordyke Messingham, Vladimir P. Badovinac, John T. Harty

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Listeria monocytogenes infection generates major histocompatibility complex (MHC) class Ia-restricted and MHC class Ib-(H2-M3)-restricted effector and memory CD8+ T cells. However, only MHC class Ia-restricted memory cells expand after rechallenge, and it is unknown if MHC class Ib-restricted memory CD8+ T cells generated by vaccination are protective. We show here that H2-M3-restricted memory CD8+ T cells were capable of secondary expansion but, in contrast to primary H2-M3-restricted effector cells, failed to provide protective immunity. In LM-immune mice, MHC class Ia-restricted memory CD8+ T cells prevented the expansion of H2-M3-restricted memory T cell populations by limiting dendritic cell antigen presentation. Thus, protective immunity by H2-M3-resricted T cells is limited to primary infection, indicating that memory MHC class Ia-restricted T cells prevent nonessential immune responses during secondary infection.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalNature immunology
Volume5
Issue number2
DOIs
StatePublished - Feb 2004

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