Methylene Blue - A therapeutic dye for all seasons?

M. Wainwright, K. B. Crossley

Research output: Contribution to journalReview articlepeer-review

301 Scopus citations


Since it was first synthesised in 1876, Methylene Blue (MB) has found uses in many different areas of clinical medicine, ranging from dementia to cancer chemotherapy. In addition, MB formed the basis of antimicrobial chemotherapy - particularly in the area of antimalarials - and eventually led to the discovery of the neuroleptic drug families. More recently, the photosensitising potential of MB and its congeners has been recognised, and these are being applied in various antimicrobial fields, especially that of blood disinfection. The range of activities of MB is due to the combination of its simple chemical structure and facility for oxidation-reduction reactions in situ.

Original languageEnglish (US)
Pages (from-to)431-443
Number of pages13
JournalJournal of Chemotherapy
Issue number5
StatePublished - Oct 2002


  • Anticancer
  • Antimicrobial
  • Blood
  • DNA
  • Malaria
  • Methylene Blue
  • Neuroleptic


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