Methotrexate-induced Hepatic Necrosis Requiring Liver Transplantation in a Patient with Rheumatoid Arthritis

N. S. Hakim, B. Kobienia, E. Benedetti, J. Bloomer, William D Payne

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.

Original languageEnglish (US)
Pages (from-to)224-225
Number of pages2
JournalInternational Surgery
Volume83
Issue number3
StatePublished - Jul 1 1998

Keywords

  • Hepatic necrosis
  • Liver transplantation
  • Methotrexate
  • Rheumatoid arthritis

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