METHODS FOR SIMULTANEOUSLY OBTAINING ENDOCARDIAL AND EPICARDIAL ELECTROPHYSIOLOGY MAPS FROM REANIMATED SWINE HEARTS

Cardiac electrophysiology plays pivotal roles for both diagnosing and treating heart rhythm disorders; relying on generated anatomic electrical mapping for providing critical insights into the given patient’s cardiac conduction. This study merges Visible Heart methodologies with Medtronic’s Affera endocardial and CardioInsight epicardial mapping systems to concurrently explore activation and repolarization patterns within reanimated swine hearts. By integrating these systems, we aimed to comprehensively characterize functional electrophysiology and hemodynamic responses while assessing therapeutic interventions: like ablation procedures and implantable devices. The integration allowed us to observe and correlate endocardial and epicardial electrical activities and associated hemodynamics during sinus rhythm and post-procedures, offering unique insights into cardiac conduction dynamics and device-tissue interactions. Despite the complexities of employing the combined systems, clinically this integrated approach unveils promising implications for tailored patient-specific therapies and advancements in cardiac interventions.