Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer

Stephanie A. Smith-Warner, Donna Spiegelman, John Ritz, Demetrius Albanes, W. Lawrence Beeson, Leslie Bernstein, Franco Berrino, Piet A. Van Den Brandt, Julie E. Buring, Eunyoung Cho, Graham A. Colditz, Aaron R. Folsom, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lisa Harnack, Pamela L. Horn-Ross, Vittorio Krogh, Michael F. LeitzmannMarjorie L. McCullough, Anthony B. Miller, Carmen Rodriguez, Thomas E. Rohan, Arthur Schatzkin, Roy Shore, Mikko Virtanen, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Shumin M. Zhang, David J. Hunter

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations

Abstract

With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined.

Original languageEnglish (US)
Pages (from-to)1053-1064
Number of pages12
JournalAmerican journal of epidemiology
Volume163
Issue number11
DOIs
StatePublished - Jun 2006

Bibliographical note

Funding Information:
This research was funded by National Institutes of Health grants CA55075 and CA78548. The work was performed at the Harvard School of Public Health (Boston, Massachusetts). Conflict of interest: none declared.

Keywords

  • Cohort studies
  • Diet
  • Epidemiologic methods
  • Meta-analysis
  • Neoplasms

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