Methodological quality and synthesis of case series and case reports

Mohammad Hassan Murad, Shahnaz Sultan, Samir Haffar, Fateh Bazerbachi

Research output: Contribution to journalArticlepeer-review

1214 Scopus citations


Case reports and case series are uncontrolled study designs known for increased risk of bias but have profoundly influenced the medical literature and continue to advance our knowledge. In this guide, we present a framework for appraisal, synthesis and application of evidence derived from case reports and case series. We propose a tool to evaluate the methodological quality of case reports and case series based on the domains of selection, ascertainment, causality and reporting and provide signalling questions to aid evidence-based practitioners and systematic reviewers in their assessment. We suggest using evidence derived from case reports and case series to inform decision-making when no other higher level of evidence is available.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalEvidence-Based Medicine
Issue number2
StatePublished - Apr 2018

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.


  • epidemiology


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