Methodological consensus on clinical proton MRS of the brain

Review and recommendations

Martin Wilson, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Alberto Bizzi, Patrick J Bolan, Kevin M. Brindle, In Young Choi, Cristina Cudalbu, Ulrike Dydak, Uzay E. Emir, Ramon G. Gonzalez, Stephan Gruber, Rolf Gruetter, Rakesh K. Gupta, Arend Heerschap, Anke Henning, Hoby P. Hetherington, Petra S. Huppi, Ralph E. Hurd & 29 others Kejal Kantarci, Risto A. Kauppinen, Dennis W.J. Klomp, Roland Kreis, Marijn J. Kruiskamp, Martin O. Leach, Alexander P. Lin, Peter R. Luijten, Malgorzata Marjanska, Andrew A. Maudsley, Dieter J. Meyerhoff, Carolyn E. Mountford, Paul G. Mullins, James B. Murdoch, Sarah J. Nelson, Ralph Noeske, Gulin Oz, Julie W. Pan, Andrew C. Peet, Harish Poptani, Stefan Posse, Eva Maria Ratai, Nouha Salibi, Tom W.J. Scheenen, Ian C.P. Smith, Brian J. Soher, Ivan Tkáč, Daniel B. Vigneron, Franklyn A. Howe

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing factor. Considerable progress has been made by the research community to address many of these challenges, and in this paper a consensus is presented on deficiencies in widely available MRS methodology and validated improvements that are currently in routine use at several clinical research institutions. In particular, the localization error for the PRESS localization sequence was found to be unacceptably high at 3 T, and use of the semi-adiabatic localization by adiabatic selective refocusing sequence is a recommended solution. Incorporation of simulated metabolite basis sets into analysis routines is recommended for reliably capturing the full spectral detail available from short TE acquisitions. In addition, the importance of achieving a highly homogenous static magnetic field (B 0 ) in the acquisition region is emphasized, and the limitations of current methods and hardware are discussed. Most recommendations require only software improvements, greatly enhancing the capabilities of clinical MRS on existing hardware. Implementation of these recommendations should strengthen current clinical applications and advance progress toward developing and validating new MRS biomarkers for clinical use.

Original languageEnglish (US)
Pages (from-to)527-550
Number of pages24
JournalMagnetic resonance in medicine
Volume82
Issue number2
DOIs
StatePublished - Aug 1 2019

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Protons
Brain
Brain Diseases
Magnetic Fields
Research
Software
Biomarkers

Keywords

  • MRS
  • brain
  • consensus
  • metabolites
  • semi-LASER
  • shimming

Cite this

Methodological consensus on clinical proton MRS of the brain : Review and recommendations. / Wilson, Martin; Andronesi, Ovidiu; Barker, Peter B.; Bartha, Robert; Bizzi, Alberto; Bolan, Patrick J; Brindle, Kevin M.; Choi, In Young; Cudalbu, Cristina; Dydak, Ulrike; Emir, Uzay E.; Gonzalez, Ramon G.; Gruber, Stephan; Gruetter, Rolf; Gupta, Rakesh K.; Heerschap, Arend; Henning, Anke; Hetherington, Hoby P.; Huppi, Petra S.; Hurd, Ralph E.; Kantarci, Kejal; Kauppinen, Risto A.; Klomp, Dennis W.J.; Kreis, Roland; Kruiskamp, Marijn J.; Leach, Martin O.; Lin, Alexander P.; Luijten, Peter R.; Marjanska, Malgorzata; Maudsley, Andrew A.; Meyerhoff, Dieter J.; Mountford, Carolyn E.; Mullins, Paul G.; Murdoch, James B.; Nelson, Sarah J.; Noeske, Ralph; Oz, Gulin; Pan, Julie W.; Peet, Andrew C.; Poptani, Harish; Posse, Stefan; Ratai, Eva Maria; Salibi, Nouha; Scheenen, Tom W.J.; Smith, Ian C.P.; Soher, Brian J.; Tkáč, Ivan; Vigneron, Daniel B.; Howe, Franklyn A.

In: Magnetic resonance in medicine, Vol. 82, No. 2, 01.08.2019, p. 527-550.

Research output: Contribution to journalReview article

Wilson, M, Andronesi, O, Barker, PB, Bartha, R, Bizzi, A, Bolan, PJ, Brindle, KM, Choi, IY, Cudalbu, C, Dydak, U, Emir, UE, Gonzalez, RG, Gruber, S, Gruetter, R, Gupta, RK, Heerschap, A, Henning, A, Hetherington, HP, Huppi, PS, Hurd, RE, Kantarci, K, Kauppinen, RA, Klomp, DWJ, Kreis, R, Kruiskamp, MJ, Leach, MO, Lin, AP, Luijten, PR, Marjanska, M, Maudsley, AA, Meyerhoff, DJ, Mountford, CE, Mullins, PG, Murdoch, JB, Nelson, SJ, Noeske, R, Oz, G, Pan, JW, Peet, AC, Poptani, H, Posse, S, Ratai, EM, Salibi, N, Scheenen, TWJ, Smith, ICP, Soher, BJ, Tkáč, I, Vigneron, DB & Howe, FA 2019, 'Methodological consensus on clinical proton MRS of the brain: Review and recommendations', Magnetic resonance in medicine, vol. 82, no. 2, pp. 527-550. https://doi.org/10.1002/mrm.27742
Wilson, Martin ; Andronesi, Ovidiu ; Barker, Peter B. ; Bartha, Robert ; Bizzi, Alberto ; Bolan, Patrick J ; Brindle, Kevin M. ; Choi, In Young ; Cudalbu, Cristina ; Dydak, Ulrike ; Emir, Uzay E. ; Gonzalez, Ramon G. ; Gruber, Stephan ; Gruetter, Rolf ; Gupta, Rakesh K. ; Heerschap, Arend ; Henning, Anke ; Hetherington, Hoby P. ; Huppi, Petra S. ; Hurd, Ralph E. ; Kantarci, Kejal ; Kauppinen, Risto A. ; Klomp, Dennis W.J. ; Kreis, Roland ; Kruiskamp, Marijn J. ; Leach, Martin O. ; Lin, Alexander P. ; Luijten, Peter R. ; Marjanska, Malgorzata ; Maudsley, Andrew A. ; Meyerhoff, Dieter J. ; Mountford, Carolyn E. ; Mullins, Paul G. ; Murdoch, James B. ; Nelson, Sarah J. ; Noeske, Ralph ; Oz, Gulin ; Pan, Julie W. ; Peet, Andrew C. ; Poptani, Harish ; Posse, Stefan ; Ratai, Eva Maria ; Salibi, Nouha ; Scheenen, Tom W.J. ; Smith, Ian C.P. ; Soher, Brian J. ; Tkáč, Ivan ; Vigneron, Daniel B. ; Howe, Franklyn A. / Methodological consensus on clinical proton MRS of the brain : Review and recommendations. In: Magnetic resonance in medicine. 2019 ; Vol. 82, No. 2. pp. 527-550.
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abstract = "Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing factor. Considerable progress has been made by the research community to address many of these challenges, and in this paper a consensus is presented on deficiencies in widely available MRS methodology and validated improvements that are currently in routine use at several clinical research institutions. In particular, the localization error for the PRESS localization sequence was found to be unacceptably high at 3 T, and use of the semi-adiabatic localization by adiabatic selective refocusing sequence is a recommended solution. Incorporation of simulated metabolite basis sets into analysis routines is recommended for reliably capturing the full spectral detail available from short TE acquisitions. In addition, the importance of achieving a highly homogenous static magnetic field (B 0 ) in the acquisition region is emphasized, and the limitations of current methods and hardware are discussed. Most recommendations require only software improvements, greatly enhancing the capabilities of clinical MRS on existing hardware. Implementation of these recommendations should strengthen current clinical applications and advance progress toward developing and validating new MRS biomarkers for clinical use.",
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AU - Wilson, Martin

AU - Andronesi, Ovidiu

AU - Barker, Peter B.

AU - Bartha, Robert

AU - Bizzi, Alberto

AU - Bolan, Patrick J

AU - Brindle, Kevin M.

AU - Choi, In Young

AU - Cudalbu, Cristina

AU - Dydak, Ulrike

AU - Emir, Uzay E.

AU - Gonzalez, Ramon G.

AU - Gruber, Stephan

AU - Gruetter, Rolf

AU - Gupta, Rakesh K.

AU - Heerschap, Arend

AU - Henning, Anke

AU - Hetherington, Hoby P.

AU - Huppi, Petra S.

AU - Hurd, Ralph E.

AU - Kantarci, Kejal

AU - Kauppinen, Risto A.

AU - Klomp, Dennis W.J.

AU - Kreis, Roland

AU - Kruiskamp, Marijn J.

AU - Leach, Martin O.

AU - Lin, Alexander P.

AU - Luijten, Peter R.

AU - Marjanska, Malgorzata

AU - Maudsley, Andrew A.

AU - Meyerhoff, Dieter J.

AU - Mountford, Carolyn E.

AU - Mullins, Paul G.

AU - Murdoch, James B.

AU - Nelson, Sarah J.

AU - Noeske, Ralph

AU - Oz, Gulin

AU - Pan, Julie W.

AU - Peet, Andrew C.

AU - Poptani, Harish

AU - Posse, Stefan

AU - Ratai, Eva Maria

AU - Salibi, Nouha

AU - Scheenen, Tom W.J.

AU - Smith, Ian C.P.

AU - Soher, Brian J.

AU - Tkáč, Ivan

AU - Vigneron, Daniel B.

AU - Howe, Franklyn A.

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KW - consensus

KW - metabolites

KW - semi-LASER

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