Method to enhance thrombomodulin APC generation using cationic proteins

Research output: Contribution to journalArticle


A method of inhibiting blood coagulation in a patient is provided. This method involves administering to the patient an effective anticoagulant amount of a cationic protein; wherein the cationic protein has an isoelectric point of at least about 7.4, and is capable of enhancing the production of activated protein C by a thrombomodulin-thrombin complex by a factor of at least about two. A particularly preferred cationic protein is purified Platelet Factor 4.

Original languageEnglish (US)
Number of pages1
JournalBiotechnology Advances
Issue number3-4
StatePublished - Jan 1 1997

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