Abstract
Hepatic resection of liver metastases of non-colorectal, non-neuroendocrine, and non-sarcoma (NCNNNS) primary malignancies seems to improve survival in selected patients. The aims of the current review were to describe long-term results of surgery and to evaluate prognostic factors for survival in patients who underwent resection of NCNNNS liver metastases. Methods: We identified 30 full texts (25 single-center and 5 multicenter studies) published after year 1995 and published in English with a total of 3849 patients. For NCNNNS liver metastases, 83.4 % of these subjects were resected. Results: No prior systematic reviews or meta-analyses on this topic were identified. All studies were case series without matching control groups. The most common primary sites were breast (23.8 %), genito-urinary (21.8 %), and gastrointestinal tract (19.8 %). The median 5- and 10-year overall survival were 32.3 % (range 19-42 %) and 24 % (indicated only in two studies, range 23-25 %), respectively, with 71 % of R0 resections. Conclusions: There is evidence suggesting that surgery of NCNNNS metastases is safe, feasible, and effective if treatment is part of a multidisciplinary approach and if indication is based on the prognostic factors underlined in literature analysis.
Original language | English (US) |
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Article number | 191 |
Journal | World Journal of Surgical Oncology |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - May 29 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Uggeri et al.
Keywords
- Liver metastases
- Liver resection
- Non-colorectal
- Non-neuroendocrine
- Non-sarcoma
- Prognostic factors