Metalloprotein enabled redox signal transduction in microbes

Murphi T. Williams, Eaindra Yee, Grant W. Larson, Elizabeth A. Apiche, Anoop Rama Damodaran, Ambika Bhagi-Damodaran

Research output: Contribution to journalReview articlepeer-review


Microbes utilize numerous metal cofactor-containing proteins to recognize and respond to constantly fluctuating redox stresses in their environment. Gaining an understanding of how these metalloproteins sense redox events, and how they communicate such information downstream to DNA to modulate microbial metabolism, is a topic of great interest to both chemists and biologists. In this article, we review recently characterized examples of metalloprotein sensors, focusing on the coordination and oxidation state of the metals involved, how these metals are able to recognize redox stimuli, and how the signal is transmitted beyond the metal center. We discuss specific examples of iron, nickel, and manganese-based microbial sensors, and identify gaps in knowledge in the field of metalloprotein-based signal transduction pathways.

Original languageEnglish (US)
Article number102331
JournalCurrent opinion in chemical biology
StatePublished - Oct 2023

Bibliographical note

Funding Information:
This work was supported by the Regents of the University of Minnesota and NIH NIGMS grant #R35GM138277.

Publisher Copyright:
© 2023 Elsevier Ltd

PubMed: MeSH publication types

  • Journal Article
  • Review


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