Metachronanalysis of circannual and circasemiannual characteristics of human suprachiasmatic vasopressin-containing neurons

A. Portela, Germaine G Cornelissen-Guillaume, F. Halberg, F. Halberg, J. Halberg, M. A. Hofman, D. F. Swaab, O. C. Ikonomou, A. G. Stoynev

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We here test for and detect anticipated about-yearly (circannual) changes in the volume and number of vasopressin-containing neurons in the human suprachiasmatic nucleus. We then resolve inferential statistical parameters quantifying the extent and timing (the amplitude and acrophase) of the circannual rhythm previously missed by data inspection and classical biometry. We parametrize about-half-yearly changes previously validated by non-parametric statistical tests. New dynamic circannual and circasemiannual endpoints thus become available for basic investigation and the assessment of disease risk elevation and/or chronoprotopathology. It was earlier demonstrated that the circannual rhythms of prolactin and TSH are prominent classifiers of individuals at high versus low familial and other risk for developing breast or prostate cancer. Any neurocrine or neural mechanisms contributing to this classification are now amenable to study, on a population basis, with the dynamic hypothalamic rhythm characteristics yielded by this metachronanalysis.

Original languageEnglish (US)
Pages (from-to)347-358
Number of pages12
JournalIn Vivo
Volume9
Issue number4
StatePublished - Jan 1 1995

Keywords

  • Chronobiology
  • Circannual
  • Circasemiannual
  • Infradian
  • Rhythm
  • Suprachiasmatic nucleus
  • Vasopressin neuron

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