Metabolomics Pilot Study Identifies Desynchronization of 24-H Rhythms and Distinct Intra-patient Variability Patterns in Critical Illness: A Preliminary Report

Keyphrases

• Metabolomics 100%
• Critical Illness 100%
• Intensive Care Unit Patients 100%
• Desynchronization 100%
• Variability Pattern 100%
• Inter-patient Variability 100%
• Healthy Controls 60%
• 24-h Rhythm 50%
• Circadian Rhythm 30%
• Metabolic Profiling 20%
• Plasma Metabolites 20%
• Pathophysiology 10%
• Clinical Course 10%
• Blood Pressure 10%
• Metabolism 10%
• Plasma Samples 10%
• Heart Rate 10%
• Mass Spectrometry 10%
• Physiologic 10%
• Patient Care 10%
• Heart Blood 10%
• Circadian System 10%
• Environmental Conditions 10%
• Intensive Care Unit 10%
• Vital Signs 10%
• Cortisol 10%
• Patient Relatives 10%
• Underlying Disease 10%
• Principal Coordinate Analysis (PCoA) 10%
• Sound Level 10%
• Control Room 10%
• Cosinor Method 10%
• Single Cluster 10%
• Daily Rhythm 10%
• Patient Room 10%
• Plasma Metabolomics 10%
• Sample Clustering 10%
• Average Noise Level 10%
• Patient Samples 10%

Biochemistry, Genetics and Molecular Biology

• Metabolomics 100%
• Rhythm 100%
• Blood Plasma 55%
• Circadian Rhythm 33%
• Metabolite 22%
• Metabolic Pathway 11%
• Principal Component Analysis 11%
• Blood Pressure 11%
• Mass Spectrometry 11%
• Sound Intensity 11%
• Cortisol 11%

Neuroscience

• Blood Plasma 100%
• Circadian Rhythm 60%
• Cortisol 20%
• Mass Spectrometry 20%
• Metabolic Pathway 20%