Abstract
Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 ug/24 h, respectively. The results of this study provide the first evidence for metabolites of tobacco-specific nitrosamines in human urine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 721-724 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 53 |
| Issue number | 4 |
| State | Published - Feb 1993 |
