Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma

Y. J. Abul-Hajj

doi:10.1016/0039-128X(75)90068-9

Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma

Y. J. Abul-Hajj

Medicinal Chemistry

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Abstract

The metabolism of 7α- ³H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.

Original language	English (US)
Pages (from-to)	488-500
Number of pages	13
Journal	Steroids
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/0039-128X(75)90068-9
State	Published - Oct 1975

Bibliographical note

Funding Information:
The author wishes to thank Drs. V. Nassar, Pathologist; K. Bikhazi, Surgeon and I. Salti of the American University Hospital, Beirut, Lebanon, for their continued cooperation and support during this project. This work has been supported in part by a grant from the Graduate Schol, University of Minnesota.

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title = "Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma",

abstract = "The metabolism of 7α- 3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.",

author = "Abul-Hajj, {Y. J.}",

note = "Funding Information: The author wishes to thank Drs. V. Nassar, Pathologist; K. Bikhazi, Surgeon and I. Salti of the American University Hospital, Beirut, Lebanon, for their continued cooperation and support during this project. This work has been supported in part by a grant from the Graduate Schol, University of Minnesota.",

year = "1975",

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N1 - Funding Information: The author wishes to thank Drs. V. Nassar, Pathologist; K. Bikhazi, Surgeon and I. Salti of the American University Hospital, Beirut, Lebanon, for their continued cooperation and support during this project. This work has been supported in part by a grant from the Graduate Schol, University of Minnesota.

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N2 - The metabolism of 7α- 3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.

AB - The metabolism of 7α- 3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.

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Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma

Abstract

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