The metabolism of 7α- 3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.
Bibliographical noteFunding Information:
The author wishes to thank Drs. V. Nassar, Pathologist; K. Bikhazi, Surgeon and I. Salti of the American University Hospital, Beirut, Lebanon, for their continued cooperation and support during this project. This work has been supported in part by a grant from the Graduate Schol, University of Minnesota.