Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma

Y. J. Abul-Hajj

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The metabolism of 7α- 3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5α-androstane-3α, 17β-diol and 5α-androstane-3, 17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.

Original languageEnglish (US)
Pages (from-to)488-500
Number of pages13
JournalSteroids
Volume26
Issue number4
DOIs
StatePublished - Oct 1975

Bibliographical note

Funding Information:
The author wishes to thank Drs. V. Nassar, Pathologist; K. Bikhazi, Surgeon and I. Salti of the American University Hospital, Beirut, Lebanon, for their continued cooperation and support during this project. This work has been supported in part by a grant from the Graduate Schol, University of Minnesota.

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