Metabolism of Carbon Monoxide by the Colonic Flora of Humans

Allen S. Levine, John H. Bond, Robin A. Prentiss, Michael D. Levitt

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The metabolism of carbon monoxide by the colonic flora was investigated using human fecal homogenates. During anaerobic incubation, these homogenates rapidly consumed added carbon monoxide reducing the PCO level to a minimum of about 0.2 ppm. In the presence of glucose, carbon monoxide consumption averaged about 0.7 ml/h · g feces and without glucose about 0.2 ml/h · g feces. This consumption was not observed if the homogenates were autoclaved, passed through a bacterial filter, or cultured aerobically, indicating that the carbon monoxide was removed by the metabolism of fecal anaerobes. Aerobic incubation of fecal homogenates resulted in slow but definite release of carbon monoxide. While bacterial carbon monoxide consumption probably does not play an appreciable role in the turnover of carbon monoxide that is inhaled or exogenously produced, it is possible that carbon monoxide uptake by colonic flora protects other fecal organisms and possibly the host from carbon monoxide liberated in the gut.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalGastroenterology
Volume83
Issue number3
DOIs
StatePublished - Jan 1 1982

Fingerprint

Carbon Monoxide
Feces
Glucose

Cite this

Metabolism of Carbon Monoxide by the Colonic Flora of Humans. / Levine, Allen S.; Bond, John H.; Prentiss, Robin A.; Levitt, Michael D.

In: Gastroenterology, Vol. 83, No. 3, 01.01.1982, p. 633-637.

Research output: Contribution to journalArticle

Levine, Allen S. ; Bond, John H. ; Prentiss, Robin A. ; Levitt, Michael D. / Metabolism of Carbon Monoxide by the Colonic Flora of Humans. In: Gastroenterology. 1982 ; Vol. 83, No. 3. pp. 633-637.
@article{f7dbc57b377d4cffa7ef4994ade60706,
title = "Metabolism of Carbon Monoxide by the Colonic Flora of Humans",
abstract = "The metabolism of carbon monoxide by the colonic flora was investigated using human fecal homogenates. During anaerobic incubation, these homogenates rapidly consumed added carbon monoxide reducing the PCO level to a minimum of about 0.2 ppm. In the presence of glucose, carbon monoxide consumption averaged about 0.7 ml/h · g feces and without glucose about 0.2 ml/h · g feces. This consumption was not observed if the homogenates were autoclaved, passed through a bacterial filter, or cultured aerobically, indicating that the carbon monoxide was removed by the metabolism of fecal anaerobes. Aerobic incubation of fecal homogenates resulted in slow but definite release of carbon monoxide. While bacterial carbon monoxide consumption probably does not play an appreciable role in the turnover of carbon monoxide that is inhaled or exogenously produced, it is possible that carbon monoxide uptake by colonic flora protects other fecal organisms and possibly the host from carbon monoxide liberated in the gut.",
author = "Levine, {Allen S.} and Bond, {John H.} and Prentiss, {Robin A.} and Levitt, {Michael D.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/S0016-5085(82)80200-X",
language = "English (US)",
volume = "83",
pages = "633--637",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Metabolism of Carbon Monoxide by the Colonic Flora of Humans

AU - Levine, Allen S.

AU - Bond, John H.

AU - Prentiss, Robin A.

AU - Levitt, Michael D.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - The metabolism of carbon monoxide by the colonic flora was investigated using human fecal homogenates. During anaerobic incubation, these homogenates rapidly consumed added carbon monoxide reducing the PCO level to a minimum of about 0.2 ppm. In the presence of glucose, carbon monoxide consumption averaged about 0.7 ml/h · g feces and without glucose about 0.2 ml/h · g feces. This consumption was not observed if the homogenates were autoclaved, passed through a bacterial filter, or cultured aerobically, indicating that the carbon monoxide was removed by the metabolism of fecal anaerobes. Aerobic incubation of fecal homogenates resulted in slow but definite release of carbon monoxide. While bacterial carbon monoxide consumption probably does not play an appreciable role in the turnover of carbon monoxide that is inhaled or exogenously produced, it is possible that carbon monoxide uptake by colonic flora protects other fecal organisms and possibly the host from carbon monoxide liberated in the gut.

AB - The metabolism of carbon monoxide by the colonic flora was investigated using human fecal homogenates. During anaerobic incubation, these homogenates rapidly consumed added carbon monoxide reducing the PCO level to a minimum of about 0.2 ppm. In the presence of glucose, carbon monoxide consumption averaged about 0.7 ml/h · g feces and without glucose about 0.2 ml/h · g feces. This consumption was not observed if the homogenates were autoclaved, passed through a bacterial filter, or cultured aerobically, indicating that the carbon monoxide was removed by the metabolism of fecal anaerobes. Aerobic incubation of fecal homogenates resulted in slow but definite release of carbon monoxide. While bacterial carbon monoxide consumption probably does not play an appreciable role in the turnover of carbon monoxide that is inhaled or exogenously produced, it is possible that carbon monoxide uptake by colonic flora protects other fecal organisms and possibly the host from carbon monoxide liberated in the gut.

UR - http://www.scopus.com/inward/record.url?scp=0019998125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019998125&partnerID=8YFLogxK

U2 - 10.1016/S0016-5085(82)80200-X

DO - 10.1016/S0016-5085(82)80200-X

M3 - Article

C2 - 7095366

AN - SCOPUS:0019998125

VL - 83

SP - 633

EP - 637

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -