Abstract
Tobacco-specific nitrosamines are the most abundant strong carcinogens in smokeless tobacco products. This chapter focuses on three of the most important of these compounds: N'-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). The carcinogenic activities of NNN, NNK, and NNAL are discussed, and the metabolic pathways of these carcinogens are presented. Specific metabolite biomarkers have been developed to assess exposure to tobacco-specific nitrosamines in smokeless tobacco users; these are presented and discussed. DNA and protein adduct formation by tobacco-specific nitrosamines are also summarized, based mainly on studies in laboratory animals.
Original language | English (US) |
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Title of host publication | Smokeless Tobacco Products |
Subtitle of host publication | Characteristics, Usage, Health Effects, and Regulatory Implications |
Publisher | Elsevier |
Pages | 151-166 |
Number of pages | 16 |
ISBN (Electronic) | 9780128181591 |
ISBN (Print) | 9780128181584 |
DOIs | |
State | Published - Jan 21 2020 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Inc. All rights reserved.
Keywords
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- Carcinogenicity
- DNA adducts
- Metabolism
- N'-nitrosonornicotine (NNN)
- Protein adducts
- Smokeless tobacco
- Tobacco-specific nitrosamines
- Urinary metabolite biomarkers