Metabolic versatility in methanogens

Kyle C. Costa, John A. Leigh

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations


Methanogenesis is an anaerobic metabolism responsible for the generation of >90% of the methane formed on Earth today, with important implications for fuels production and global warming. Although methanogenic Archaea have been cultured for over 70 years, key insights regarding electron flow and energy conservation in methanogenesis have only recently emerged. Fundamental differences between two metabolic types of methanogenesis, hydrogenotrophic and methylotrophic, are now understood, with implications for metabolic versatility and the potential for engineering of methanogens to utilize new substrates. The development of model species with genetic and bioinformatic tools has advanced the field and holds potential for further characterizing and engineering of methanogenesis. Our understanding of a related pathway, anaerobic methane oxidation, is in its infancy.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalCurrent opinion in biotechnology
Issue number1
StatePublished - Oct 2014
Externally publishedYes

Bibliographical note

Funding Information:
Work in the authors’ laboratory is supported by the Chemical Sciences , Geosciences and Biosciences Division , Office of Basic Energy Sciences , Office of Science , U.S. Department of Energy grant DE-FG02-05ER15709 .


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