Metabolic profiling and biological activities of artabotrys hexapetalus (L.F.) bandari leaves

Balamurugan Pandiyan, Sangilimuthu Alagar Yadav, Lukmanul Hakkim Faruck, Hamid Bakshi

Research output: Contribution to journalArticlepeer-review


Artabotrys hexapetalus (L.f.) Bandari an endemic shrub in India producing fragrant flowers belongs to Annonaceae family and is mainly used traditionally for the treatment of cholera and scrofula. The present study reveals antimicrobial, antioxidant and anticancer activities of Artabotrys hexapetalus.To screening and evaluate the major secondary metabolites presents, antioxidant, anticancer potential by in vitro assay in A.hexapetalus leaves. All successive extracts of Artabotrys hexapetalus with ethyl ethanoate, chloroform, methanol, ethanol were obtained by Soxhlet method and subjected to phytochemical screening and in vitro antioxidant activity. Antibacterial activity and anticancer activity were determined by Disc diffusion and MTT methods, respectively. Compared to other solvents extracts, the methanol extract of A.hexapetalus contains the higher phenolic content (48.45 µg/mg), flavonoid content (49.15 µg/mg) and potential antioxidant capacity (IC50:10.15 ± 0.85 µg/mg). Due to the high potential of methanol extract of A hexapetalus was subjected to the separation of active molecules. Further, trisaccha-ride, n-Hexadecanoic acid and Z-8-Methyl-9-tetradecenoic acid was isolated and charecterised by UV-vis, FT-IR, NMR spectral studies. Trisaccharide and partially separated fractions from A.hexapetalus contain higher antioxidant, anticancer (MCF-7) and antimicrobial activity. Here we conclude that, the methanol extract of A.hexapetalus leaves and their fractions possess highly activities against various free radicals, human pathogens and cancer cell line (MCF-7). This is the primary lead to make a new biological agent from A.hexapetalus leaves.

Original languageEnglish (US)
Pages (from-to)2371-2382
Number of pages12
JournalInternational Journal of Research in Pharmaceutical Sciences
Issue number2
StatePublished - Apr 11 2020
Externally publishedYes

Bibliographical note

Funding Information:
Authors gratefully acknowledge Karpagam Academy of Higher Education for providing the laboratory facility and acknowledge DST-FIST (File No.SR/FST/LS-1/2018/187) for funds to conduct this work.

Publisher Copyright:
© 2020, J. K. Welfare and Pharmascope Foundation. All rights reserved.


  • Antioxidant activity
  • Artabotrys hexapetalus
  • Cytotoxicity
  • Flavonoid content
  • MCF-7
  • Phenolic
  • Phytoconstituents


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