Metabolic myocardial protection with allopurinol during cardiopulmonary bypass and aortic cross clamping

W. G. Lindsay, L. H. Toledo Pereyra, John E Foker, R. L. Vardo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The study was undertaken to determine if the use of allopurinol, prior to instituting cardiopulmonary bypass, would protect the myocardium during periods of normothermic arrest, with the ascending aorta cross clamped. The exact mechanism of this apparent protective effect is not known. However, allopurinol does inhibit the catabolic breakdown of adenine, which may provide adenine nucleotides for the regeneration of higher energy phosphate bonds.

Original languageEnglish (US)
Pages (from-to)259-260
Number of pages2
JournalSurgical Forum
VolumeVol.26
StatePublished - Jan 1 1975

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