Metabolic correlatives of brain activity in a FOS epilepsy patient

Stefano Peca, Marco Carnì, Carlo Di Bonaventura, Teresa Aprile, Gisela E. Hagberg, Anna Teresa Giallonardo, Mario Manfredi, Silvia Mangia, Girolamo Garreffa, Bruno Maraviglia, Federico Giove

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The correlation and the interactions between neuronal activity and underlying metabolic dynamics are still a matter of debate, especially in pathological conditions. This study reports findings obtained on a subject suffering from fixation-off sensitivity (FOS) epilepsy, exploited as a model system of triggerable anomalous electrical activity. Functional Magnetic Resonance Spectroscopy was used to investigate the metabolic response to visual spike-inducing stimuli in a single voxel placed in the temporo-occipital lobe of a FOS epilepsy patient. MRS measurements were additionally performed on a control group of five healthy volunteers. The FOS patient also underwent an EEG session with the same stimulus paradigm. Uniquely in the FOS patient, glutamate and glutamine concentration increased during the first 10 min of stimulation and then returned to baseline. On the other hand, FOS-induced epileptic activity (spiking) endured throughout all the stimulation epoch. The observed metabolic dynamics may be likely linked to a complex interplay between alterations of the metabolic pathways of glutamate and modulation of the neuronal activity.

Original languageEnglish (US)
Pages (from-to)170-178
Number of pages9
JournalNMR in biomedicine
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Glutamic Acid
Epilepsy
Brain
Magnetic resonance spectroscopy
Electroencephalography
Glutamine
Occipital Lobe
Modulation
Metabolic Networks and Pathways
Psychological Stress
Healthy Volunteers
Magnetic Resonance Spectroscopy
Control Groups

Keywords

  • EEG
  • Epilepsy
  • Fixation-off sensitivity
  • Functional magnetic resonance spectroscopy
  • Glutamate
  • Glutamine

Cite this

Peca, S., Carnì, M., Di Bonaventura, C., Aprile, T., Hagberg, G. E., Giallonardo, A. T., ... Giove, F. (2010). Metabolic correlatives of brain activity in a FOS epilepsy patient. NMR in biomedicine, 23(2), 170-178. https://doi.org/10.1002/nbm.1439

Metabolic correlatives of brain activity in a FOS epilepsy patient. / Peca, Stefano; Carnì, Marco; Di Bonaventura, Carlo; Aprile, Teresa; Hagberg, Gisela E.; Giallonardo, Anna Teresa; Manfredi, Mario; Mangia, Silvia; Garreffa, Girolamo; Maraviglia, Bruno; Giove, Federico.

In: NMR in biomedicine, Vol. 23, No. 2, 01.02.2010, p. 170-178.

Research output: Contribution to journalArticle

Peca, S, Carnì, M, Di Bonaventura, C, Aprile, T, Hagberg, GE, Giallonardo, AT, Manfredi, M, Mangia, S, Garreffa, G, Maraviglia, B & Giove, F 2010, 'Metabolic correlatives of brain activity in a FOS epilepsy patient', NMR in biomedicine, vol. 23, no. 2, pp. 170-178. https://doi.org/10.1002/nbm.1439
Peca S, Carnì M, Di Bonaventura C, Aprile T, Hagberg GE, Giallonardo AT et al. Metabolic correlatives of brain activity in a FOS epilepsy patient. NMR in biomedicine. 2010 Feb 1;23(2):170-178. https://doi.org/10.1002/nbm.1439
Peca, Stefano ; Carnì, Marco ; Di Bonaventura, Carlo ; Aprile, Teresa ; Hagberg, Gisela E. ; Giallonardo, Anna Teresa ; Manfredi, Mario ; Mangia, Silvia ; Garreffa, Girolamo ; Maraviglia, Bruno ; Giove, Federico. / Metabolic correlatives of brain activity in a FOS epilepsy patient. In: NMR in biomedicine. 2010 ; Vol. 23, No. 2. pp. 170-178.
@article{738212377ca049ce894161e9923b27a4,
title = "Metabolic correlatives of brain activity in a FOS epilepsy patient",
abstract = "The correlation and the interactions between neuronal activity and underlying metabolic dynamics are still a matter of debate, especially in pathological conditions. This study reports findings obtained on a subject suffering from fixation-off sensitivity (FOS) epilepsy, exploited as a model system of triggerable anomalous electrical activity. Functional Magnetic Resonance Spectroscopy was used to investigate the metabolic response to visual spike-inducing stimuli in a single voxel placed in the temporo-occipital lobe of a FOS epilepsy patient. MRS measurements were additionally performed on a control group of five healthy volunteers. The FOS patient also underwent an EEG session with the same stimulus paradigm. Uniquely in the FOS patient, glutamate and glutamine concentration increased during the first 10 min of stimulation and then returned to baseline. On the other hand, FOS-induced epileptic activity (spiking) endured throughout all the stimulation epoch. The observed metabolic dynamics may be likely linked to a complex interplay between alterations of the metabolic pathways of glutamate and modulation of the neuronal activity.",
keywords = "EEG, Epilepsy, Fixation-off sensitivity, Functional magnetic resonance spectroscopy, Glutamate, Glutamine",
author = "Stefano Peca and Marco Carn{\`i} and {Di Bonaventura}, Carlo and Teresa Aprile and Hagberg, {Gisela E.} and Giallonardo, {Anna Teresa} and Mario Manfredi and Silvia Mangia and Girolamo Garreffa and Bruno Maraviglia and Federico Giove",
year = "2010",
month = "2",
day = "1",
doi = "10.1002/nbm.1439",
language = "English (US)",
volume = "23",
pages = "170--178",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Metabolic correlatives of brain activity in a FOS epilepsy patient

AU - Peca, Stefano

AU - Carnì, Marco

AU - Di Bonaventura, Carlo

AU - Aprile, Teresa

AU - Hagberg, Gisela E.

AU - Giallonardo, Anna Teresa

AU - Manfredi, Mario

AU - Mangia, Silvia

AU - Garreffa, Girolamo

AU - Maraviglia, Bruno

AU - Giove, Federico

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The correlation and the interactions between neuronal activity and underlying metabolic dynamics are still a matter of debate, especially in pathological conditions. This study reports findings obtained on a subject suffering from fixation-off sensitivity (FOS) epilepsy, exploited as a model system of triggerable anomalous electrical activity. Functional Magnetic Resonance Spectroscopy was used to investigate the metabolic response to visual spike-inducing stimuli in a single voxel placed in the temporo-occipital lobe of a FOS epilepsy patient. MRS measurements were additionally performed on a control group of five healthy volunteers. The FOS patient also underwent an EEG session with the same stimulus paradigm. Uniquely in the FOS patient, glutamate and glutamine concentration increased during the first 10 min of stimulation and then returned to baseline. On the other hand, FOS-induced epileptic activity (spiking) endured throughout all the stimulation epoch. The observed metabolic dynamics may be likely linked to a complex interplay between alterations of the metabolic pathways of glutamate and modulation of the neuronal activity.

AB - The correlation and the interactions between neuronal activity and underlying metabolic dynamics are still a matter of debate, especially in pathological conditions. This study reports findings obtained on a subject suffering from fixation-off sensitivity (FOS) epilepsy, exploited as a model system of triggerable anomalous electrical activity. Functional Magnetic Resonance Spectroscopy was used to investigate the metabolic response to visual spike-inducing stimuli in a single voxel placed in the temporo-occipital lobe of a FOS epilepsy patient. MRS measurements were additionally performed on a control group of five healthy volunteers. The FOS patient also underwent an EEG session with the same stimulus paradigm. Uniquely in the FOS patient, glutamate and glutamine concentration increased during the first 10 min of stimulation and then returned to baseline. On the other hand, FOS-induced epileptic activity (spiking) endured throughout all the stimulation epoch. The observed metabolic dynamics may be likely linked to a complex interplay between alterations of the metabolic pathways of glutamate and modulation of the neuronal activity.

KW - EEG

KW - Epilepsy

KW - Fixation-off sensitivity

KW - Functional magnetic resonance spectroscopy

KW - Glutamate

KW - Glutamine

UR - http://www.scopus.com/inward/record.url?scp=77149142267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77149142267&partnerID=8YFLogxK

U2 - 10.1002/nbm.1439

DO - 10.1002/nbm.1439

M3 - Article

C2 - 19839013

AN - SCOPUS:77149142267

VL - 23

SP - 170

EP - 178

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 2

ER -