Metabolic Control of Cardiomyocyte Cell Cycle

Ivan Menendez-Montes; Daniel J. Garry; Jianyi Zhang; Hesham A. Sadek

doi:10.14797/mdcvj.1309

Metabolic Control of Cardiomyocyte Cell Cycle

Ivan Menendez-Montes, Daniel J. Garry, Jianyi Zhang, Hesham A. Sadek

Medicine - Cardiology Division

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

Original language	English (US)
Pages (from-to)	26-36
Number of pages	11
Journal	Methodist DeBakey cardiovascular journal
Volume	19
Issue number	5
DOIs	https://doi.org/10.14797/mdcvj.1309
State	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s).

Keywords

cardiac regeneration
cardiomyocyte proliferation
glycolysis
oxidative phosphorylation
reactive oxygen species
uridine diphosphate N-acetylglucosamine (UDP GlycNAC)

PubMed: MeSH publication types

Journal Article
Review

Publisher link

10.14797/mdcvj.1309

Find It

Find It at U of M Libraries

Cite this

@article{6e7309893bd94bf5b7b9fde00c643d7a,

title = "Metabolic Control of Cardiomyocyte Cell Cycle",

abstract = "Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.",

keywords = "cardiac regeneration, cardiomyocyte proliferation, glycolysis, oxidative phosphorylation, reactive oxygen species, uridine diphosphate N-acetylglucosamine (UDP GlycNAC)",

author = "Ivan Menendez-Montes and Garry, {Daniel J.} and Jianyi Zhang and Sadek, {Hesham A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s).",

year = "2023",

doi = "10.14797/mdcvj.1309",

language = "English (US)",

volume = "19",

pages = "26--36",

journal = "Methodist DeBakey cardiovascular journal",

issn = "1947-6094",

publisher = "Methodist DeBakey Heart & Vascular Center",

number = "5",

}

TY - JOUR

T1 - Metabolic Control of Cardiomyocyte Cell Cycle

AU - Menendez-Montes, Ivan

AU - Garry, Daniel J.

AU - Zhang, Jianyi

AU - Sadek, Hesham A.

PY - 2023

Y1 - 2023

N2 - Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

AB - Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

KW - cardiac regeneration

KW - cardiomyocyte proliferation

KW - glycolysis

KW - oxidative phosphorylation

KW - reactive oxygen species

KW - uridine diphosphate N-acetylglucosamine (UDP GlycNAC)

UR - http://www.scopus.com/inward/record.url?scp=85178649097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85178649097&partnerID=8YFLogxK

U2 - 10.14797/mdcvj.1309

DO - 10.14797/mdcvj.1309

M3 - Review article

C2 - 38028975

AN - SCOPUS:85178649097

SN - 1947-6094

VL - 19

SP - 26

EP - 36

JO - Methodist DeBakey cardiovascular journal

JF - Methodist DeBakey cardiovascular journal

IS - 5

ER -

Metabolic Control of Cardiomyocyte Cell Cycle

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this