Metabolic activation of the cooked meat carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human prostate

Keyphrases

• Cooked Meat 100%
• Carcinogen 100%
• PhIP 100%
• Metabolic Activation 100%
• Human Prostate 100%
• 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 100%
• DNA Adducts 36%
• LNCaP Cells 36%
• N-acetyltransferase 2 (NAT2) 36%
• Heterocyclic Aromatic Amines 18%
• Recombinant 18%
• Amino 18%
• Cytotoxicity 18%
• Rodents 18%
• DNA Damage 18%
• Bioactivation 18%
• Phase II Enzymes 18%
• 2-amino-3 18%
• MeIQx 18%
• Prostate 9%
• Prostate Cancer Patients 9%
• Indole 9%
• Kinase Activity 9%
• Quinoline 9%
• Hydroxylated 9%
• High Susceptibility 9%
• DNA Binding 9%
• 1-Methyl 9%
• Cytosolic Fraction 9%
• Quinoxaline 9%
• Pyridine 9%
• DNA Adduct Formation 9%
• Specific Inhibitor 9%
• Enzyme Inhibitors 9%
• Pentachlorophenol 9%
• Phase I Enzymes 9%
• Mefenamic Acid 9%
• Sulfotransferase 9%
• SULT1A1 9%
• 2-Thioxothiazolidin-4-one 9%
• LNCaP Cell Line 9%
• Hydroxybenzylidene 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogen 100%
• Bioactivation 100%
• Aromatic Amine 100%
• Cytotoxicity 100%
• Prostate Cancer 50%
• Phosphotransferase 50%
• Indole 50%
• Quinoxaline 50%
• Pentachlorophenol 50%
• Mefenamic Acid 50%
• Enzyme Inhibitor 50%
• Sulfotransferase 50%