Meta-analysis of sequential luteal-cycle-associated changes in human breast tissue

H. W. Simpson, Germaine G Cornelissen-Guillaume, G. Katinas, F. Halberg

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We chronobiologically estimate the time relations of physiological and morphological changes in breast tissue during the luteal phase of the menstrual cycle, as a cascade led by the progesterone peak. The timing and uncertainties of maxima in epithelial mitotic frequency, breast and epithelial volume, breast surface temperature, water content, blood flow and apoptosis are given as parts of a rhythmic element in a broader time structure or chronome.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalBreast Cancer Research and Treatment
Issue number2
StatePublished - 2000


  • Breast
  • Breast surface temperature
  • Chronome
  • Luteal cycle
  • Phase analysis
  • Progesterone


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