Several large-scale meta-GWAS identified significant association between SNP rs17465637 in the MIA3 gene and coronary artery disease (CAD) in the European ancestry populations. However, three follow-up replication studies in the Chinese populations yielded inconsistent results. In order to unequivocally determine whether SNP rs17465637 is associated with CAD, we performed an independent case control association study in the Chinese Han population and a follow-up large scale meta-analysis for SNP rs17465637. Our study included 2503 CAD patients and 2920 non-CAD controls of the Chinese Han origin. A significant association was found between SNP rs17465637 and CAD (P=0.01, OR=1.11). Meta-analysis included 7263 CAD patients and 8347 controls combined from five Asian populations. The association between SNP rs17465637 and CAD became highly significant (P=4.97×10-5, OR=1.11). Similar analysis also identified significant association between SNP rs17465637 and MI (2424 cases vs. 6,536controls; P=5.00×10-3, OR=1.10). We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Nov 2013|
Bibliographical noteFunding Information:
This work was supported by the National Basic Research (973) Program grants 2012CB517801 and 2013CB0531101 , a Hubei Province Natural Science Key Program ( 2008CDA047 ), a Key Academic Program Leader Award of Wuhan City ( 200951830560 ), and a grant from the State Key Laboratory of Freshwater Ecology and Biotechnology ( 2011FB16 ).