Meta-Analysis Evaluating Outcomes of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery

Abdisamad M Ibrahim, Nitin Tandan, Cameron Koester, Mohammad Al-Akchar, Bishal Bhandari, Albert Botchway, Jumana Abdelkarim, Ruby Maini, Mohamed Labedi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Surgical left atrial appendage occlusion (S-LAAO) has become a common procedure performed in patients undergoing cardiac surgery; however, evidence to support this procedure remains inconclusive. This meta-analysis aims to assess the efficacy of S-LAAO in terms of ischemic stroke, postoperative atrial fibrillation, and all-cause mortality. A thorough literature review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We identified 10 relevant studies for our meta-analysis. It included 6,779 patients who underwent S-LAAO and 6,573 who did not undergo LAAO. In terms of ischemic stroke, the S-LAAO cohort had a lower events (pooled odds ratio [OR] 0.655 (0.518 to 0.829), p = 0.0004) compared with the non-LAAO cohort. S-LAAO cohort also had lower events of all-cause mortality (pooled OR 0.74 (95% confidence interval 0.55 to 0.99), p = 0.0408) when compared with the non-LAAO cohort. In regards to postoperative atrial fibrillation, there was no difference between the 2 groups (pooled OR 1.29 (95% confidence interval 0.81 to 2.06), p = 0.2752). In conclusion, S-LAAO was associated with lower events of ischemic stroke or systemic embolism and all-cause mortality when compared to the non-LAAO group.

Original languageEnglish (US)
Pages (from-to)1218-1225
Number of pages8
JournalThe American Journal of Cardiology
Issue number8
StatePublished - Oct 15 2019
Externally publishedYes


  • Atrial Appendage/surgery
  • Atrial Fibrillation/complications
  • Brain Ischemia/epidemiology
  • Cardiac Surgical Procedures/methods
  • Cause of Death/trends
  • Global Health
  • Humans
  • Incidence
  • Outcome Assessment, Health Care
  • Septal Occluder Device

PubMed: MeSH publication types

  • Journal Article
  • Meta-Analysis
  • Review


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