Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function

Jiayi Xu, Traci M. Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W. Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L. Booth, Guy G. Brusselle, Ian H. De Boer, Myriam Fornage, Alexis C. Frazier-Wood, Mariaelisa Graff, Vilmundur Gudnason, Tamara B. Harris, Albert Hofman, Ruixue Hou, Denise K. Houston, David R Jacobs Jr & 26 others Stephen B. Kritchevsky, Jeanne Latourelle, Rozenn N. Lemaitre, Pamela L Lutsey, George O'Connor, Elizabeth C. Oelsner, Jim Pankow, Bruce M. Psaty, Rebecca R. Rohde, Stephen S. Rich, Jerome I. Rotter, Lewis J. Smith, Bruno H. Stricker, V. Saroja Voruganti, Thomas J. Wang, M. Carola Zillikens, R. Graham Barr, Josée Dupuis, Sina A. Gharib, Lies Lahousse, Stephanie J. London, Kari E. North, Albert V. Smith, Lyn M Steffen, Dana B. Hancock, Patricia A. Cassano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

Original languageEnglish (US)
Pages (from-to)1159-1170
Number of pages12
JournalBritish Journal of Nutrition
Volume120
Issue number10
DOIs
StatePublished - Nov 28 2018

Fingerprint

Vital Capacity
Vitamin D
Meta-Analysis
Epidemiology
Lung
Forced Expiratory Volume
Serum
Research
Vulnerable Populations
Epidemiologic Studies
Linear Models
Cross-Sectional Studies
Smoking

Keywords

  • African Americans
  • Forced expiratory volume
  • Respiratory function tests
  • Smoking
  • Vital capacity
  • Vitamin D
  • Whites

PubMed: MeSH publication types

  • Journal Article
  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

Cite this

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function. / Xu, Jiayi; Bartz, Traci M.; Chittoor, Geetha; Eiriksdottir, Gudny; Manichaikul, Ani W.; Sun, Fangui; Terzikhan, Natalie; Zhou, Xia; Booth, Sarah L.; Brusselle, Guy G.; De Boer, Ian H.; Fornage, Myriam; Frazier-Wood, Alexis C.; Graff, Mariaelisa; Gudnason, Vilmundur; Harris, Tamara B.; Hofman, Albert; Hou, Ruixue; Houston, Denise K.; Jacobs Jr, David R; Kritchevsky, Stephen B.; Latourelle, Jeanne; Lemaitre, Rozenn N.; Lutsey, Pamela L; O'Connor, George; Oelsner, Elizabeth C.; Pankow, Jim; Psaty, Bruce M.; Rohde, Rebecca R.; Rich, Stephen S.; Rotter, Jerome I.; Smith, Lewis J.; Stricker, Bruno H.; Voruganti, V. Saroja; Wang, Thomas J.; Zillikens, M. Carola; Barr, R. Graham; Dupuis, Josée; Gharib, Sina A.; Lahousse, Lies; London, Stephanie J.; North, Kari E.; Smith, Albert V.; Steffen, Lyn M; Hancock, Dana B.; Cassano, Patricia A.

In: British Journal of Nutrition, Vol. 120, No. 10, 28.11.2018, p. 1159-1170.

Research output: Contribution to journalArticle

Xu, J, Bartz, TM, Chittoor, G, Eiriksdottir, G, Manichaikul, AW, Sun, F, Terzikhan, N, Zhou, X, Booth, SL, Brusselle, GG, De Boer, IH, Fornage, M, Frazier-Wood, AC, Graff, M, Gudnason, V, Harris, TB, Hofman, A, Hou, R, Houston, DK, Jacobs Jr, DR, Kritchevsky, SB, Latourelle, J, Lemaitre, RN, Lutsey, PL, O'Connor, G, Oelsner, EC, Pankow, J, Psaty, BM, Rohde, RR, Rich, SS, Rotter, JI, Smith, LJ, Stricker, BH, Voruganti, VS, Wang, TJ, Zillikens, MC, Barr, RG, Dupuis, J, Gharib, SA, Lahousse, L, London, SJ, North, KE, Smith, AV, Steffen, LM, Hancock, DB & Cassano, PA 2018, 'Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function', British Journal of Nutrition, vol. 120, no. 10, pp. 1159-1170. https://doi.org/10.1017/S0007114518002180
Xu, Jiayi ; Bartz, Traci M. ; Chittoor, Geetha ; Eiriksdottir, Gudny ; Manichaikul, Ani W. ; Sun, Fangui ; Terzikhan, Natalie ; Zhou, Xia ; Booth, Sarah L. ; Brusselle, Guy G. ; De Boer, Ian H. ; Fornage, Myriam ; Frazier-Wood, Alexis C. ; Graff, Mariaelisa ; Gudnason, Vilmundur ; Harris, Tamara B. ; Hofman, Albert ; Hou, Ruixue ; Houston, Denise K. ; Jacobs Jr, David R ; Kritchevsky, Stephen B. ; Latourelle, Jeanne ; Lemaitre, Rozenn N. ; Lutsey, Pamela L ; O'Connor, George ; Oelsner, Elizabeth C. ; Pankow, Jim ; Psaty, Bruce M. ; Rohde, Rebecca R. ; Rich, Stephen S. ; Rotter, Jerome I. ; Smith, Lewis J. ; Stricker, Bruno H. ; Voruganti, V. Saroja ; Wang, Thomas J. ; Zillikens, M. Carola ; Barr, R. Graham ; Dupuis, Josée ; Gharib, Sina A. ; Lahousse, Lies ; London, Stephanie J. ; North, Kari E. ; Smith, Albert V. ; Steffen, Lyn M ; Hancock, Dana B. ; Cassano, Patricia A. / Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function. In: British Journal of Nutrition. 2018 ; Vol. 120, No. 10. pp. 1159-1170.
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title = "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function",
abstract = "The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 {\%} CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 {\%} CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 {\%} CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 {\%} CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 {\%} CI 1·1, 2·3) for current smokers and 1·7 ml (95 {\%} CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 {\%} CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.",
keywords = "African Americans, Forced expiratory volume, Respiratory function tests, Smoking, Vital capacity, Vitamin D, Whites",
author = "Jiayi Xu and Bartz, {Traci M.} and Geetha Chittoor and Gudny Eiriksdottir and Manichaikul, {Ani W.} and Fangui Sun and Natalie Terzikhan and Xia Zhou and Booth, {Sarah L.} and Brusselle, {Guy G.} and {De Boer}, {Ian H.} and Myriam Fornage and Frazier-Wood, {Alexis C.} and Mariaelisa Graff and Vilmundur Gudnason and Harris, {Tamara B.} and Albert Hofman and Ruixue Hou and Houston, {Denise K.} and {Jacobs Jr}, {David R} and Kritchevsky, {Stephen B.} and Jeanne Latourelle and Lemaitre, {Rozenn N.} and Lutsey, {Pamela L} and George O'Connor and Oelsner, {Elizabeth C.} and Jim Pankow and Psaty, {Bruce M.} and Rohde, {Rebecca R.} and Rich, {Stephen S.} and Rotter, {Jerome I.} and Smith, {Lewis J.} and Stricker, {Bruno H.} and Voruganti, {V. Saroja} and Wang, {Thomas J.} and Zillikens, {M. Carola} and Barr, {R. Graham} and Jos{\'e}e Dupuis and Gharib, {Sina A.} and Lies Lahousse and London, {Stephanie J.} and North, {Kari E.} and Smith, {Albert V.} and Steffen, {Lyn M} and Hancock, {Dana B.} and Cassano, {Patricia A.}",
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TY - JOUR

T1 - Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function

AU - Xu, Jiayi

AU - Bartz, Traci M.

AU - Chittoor, Geetha

AU - Eiriksdottir, Gudny

AU - Manichaikul, Ani W.

AU - Sun, Fangui

AU - Terzikhan, Natalie

AU - Zhou, Xia

AU - Booth, Sarah L.

AU - Brusselle, Guy G.

AU - De Boer, Ian H.

AU - Fornage, Myriam

AU - Frazier-Wood, Alexis C.

AU - Graff, Mariaelisa

AU - Gudnason, Vilmundur

AU - Harris, Tamara B.

AU - Hofman, Albert

AU - Hou, Ruixue

AU - Houston, Denise K.

AU - Jacobs Jr, David R

AU - Kritchevsky, Stephen B.

AU - Latourelle, Jeanne

AU - Lemaitre, Rozenn N.

AU - Lutsey, Pamela L

AU - O'Connor, George

AU - Oelsner, Elizabeth C.

AU - Pankow, Jim

AU - Psaty, Bruce M.

AU - Rohde, Rebecca R.

AU - Rich, Stephen S.

AU - Rotter, Jerome I.

AU - Smith, Lewis J.

AU - Stricker, Bruno H.

AU - Voruganti, V. Saroja

AU - Wang, Thomas J.

AU - Zillikens, M. Carola

AU - Barr, R. Graham

AU - Dupuis, Josée

AU - Gharib, Sina A.

AU - Lahousse, Lies

AU - London, Stephanie J.

AU - North, Kari E.

AU - Smith, Albert V.

AU - Steffen, Lyn M

AU - Hancock, Dana B.

AU - Cassano, Patricia A.

PY - 2018/11/28

Y1 - 2018/11/28

N2 - The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

AB - The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

KW - African Americans

KW - Forced expiratory volume

KW - Respiratory function tests

KW - Smoking

KW - Vital capacity

KW - Vitamin D

KW - Whites

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