Met is required for oligodendrocyte progenitor cell migration in Danio rerio

Maria F. Ali, Andrew J. Latimer, Yinxue Wang, Leah Hogenmiller, Laura Fontenas, Adam J. Isabella, Cecilia B. Moens, Guoqiang Yu, Sarah Kucenas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development.

Original languageEnglish (US)
Article numberjkab265
JournalG3: Genes, Genomes, Genetics
Volume11
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.

Keywords

  • Glial migration
  • Met receptor
  • Oligodendrocyte progenitor cells
  • Spinal cord development
  • Zebrafish

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